"TOXICOLOGICAL EFFECTS
ACUTE TOXICITY
While the LD50 of 2,4-D suggests that it is only moderately toxic, the product carries the DANGER signal word on the label indicating that it is highly toxic. This is because 2,4-D has produced serious eye and skin irritation among agricultural workers (15,16).
The oral LD50 of 2,4-D in the rat ranges from 375 to 666 mg/kg; 370 mg/kg in the mouse; and less than 320 to 1,000 mg/kg in the guinea pig. The rat and rabbit have dermal LD50 values of 1,500 mg/kg and 1,400 mg/kg, respectively. In humans, prolonged breathing of 2,4-D causes coughing, burning, dizziness, and temporary loss of muscle coordination.
Symptoms of poisoning can be fatigue and weakness with perhaps nausea. On rare occasions there can be inflammation of the nerve endings with muscular effects following high levels of exposure (6). Symptoms vary with the different commercial products because of the specific amounts and types of additives such as surfactants and solvents. "