I bought a new 5065E with a 553 loader 5 years ago. I didn't see much use in reviewing a new tractor then, so here you go 5 years and 500 hours later.
I've had no significant issues with the tractor. The bolts holding the seat down vibrated loose and knocked the threads out. I had to fix it with a helicoil. I managed to mash the hydraulic tube that runs from the front of the tractor to the rear and had to replace that so a skid plate would help. The little "bat wing" that adjusts the lift arm up and down to level an implement vibrated loose and was lost so I had to replace that. I also had the ground cable vibrate loose. The dash panel does fog up but hasn't caused any issues.
I have the standard 12/3 transmission and any range but "A" is entirely too fast in reverse. It's also hard to start in cold weather but the dealer installed a block heater that works well and is worth the money.
Overall I recommend the tractor and would buy again. I'm currently considering another 5065E or a 5075E.