From a practical point of view... i.e. what can the truck handle... It would be helpful to know the truck and rear axle you are talking about.
From a legal point of view it is possible to get a truck re-registered at a higher GVW but few groups can do this. If you want to go this route you have to find an engineering group that can design the mods and regester your truck.
Personal experience - I have a 1999 F-250. The rear springs are rated at 4600 pounds combined and the axle and tires are rated at 6800 pounds. Breaks are the same as on the F-350. So you can see that the spring were far and away the weak link. I added air bags and eventually the springs broke, possibly due to how the air bags attach. I swaped in heavier springs, rated for 7,200 pounds combined. To my surprise, the truck rides softer with the heavier springs than it did with the originals + air bags. This is possible because the new springs give 6 inches of travel to the bump stops compared to 3 inches with the old worn out springs.
So now the weak link is the axle / tires. The back of the truck weighs 2800 pounds so I limit payloads to 4,000 pounds. It's not legal at that weight. Still has the same legal gross of 8,800 pounds based on registration. On the flip side, every component part is made to handle more and is used in heavier applications than the 8,800 pound rating. The only difference between my truck and a F-350 single rear wheel is the badge on the side and the fact the I have heavier springs than the F-350.... Practically speaking, my truck is better for hauling weight than the F-350 single rear wheel. But the F-350 can legally carry more.