Myself not being a people person, stay away from the area on the weekends whatever you do.
Be up in that area every week for work during the weekday, no problems other that App state students around, but went up on a weekend to Blowing Rock and couldn't even find a place to park!
Linville gorge one of the hardest whitewater steep creeks on the east coast, worth the hike if your up to it in that area. Biltmore is south on the Parkway, couple of hours (speed limit on the parkway is not 55!). Again, go during the week, you can tour Biltmore usually with no lines. On the weekend, you could have a line just to get into the "mansion" (sp?).
If you're around Asheville, head 70 miles or so to Greenville S.C, one of the coolest towns I've been to on a weekend. Like a big block party with great restaurants.
412 south to Wilkesboro, home of Junior Johnson, old Wilkesboro motor speedway there as well, not much to see though. Next county over (Yadkin)is big wine "country", lots of vineyards, hit 52 south and you can tour Richard Childress's vinyards along with his racing museum.
Up in Galax Va. off the parkway some great antique shops (my wife made me go!).
Funny how places change along with your views when you actually live there and are not visitng.