great stuff (red can) is a closed cell spray foam, i honestly should buy some stock in it, the way i use it.
if you get anything on you, clothes, skin, etc... let it dry and i mean totally dry. if on skin. a couple hours to do its initial curing. then once dry you can almost peal it off your skin. but if on cloths, or paneling, other wood work, and places you do not want it. then let it "fully cure" meaning not initial curing. but the 7 plus days of curing.
once it has fully cured, you can normally take your fingers and get the bigger chunks off. and then take a paint scraper, (finger nail could work but that hurts me fingers) and scrap majority of it off. on cloths you may have to wiggle the stuff back and forth. wiggle may be bad term. fold the cloth over itself and rub the 2 parts back and forth together. so the spot you want removed is the part that is constantly bending the U shape of the bend / fold of the cloth. this can help "break" stuff up and allow it to fall out of the little crevices and dents of the fabric of the cloth.
everything else that has good smooth surface, metal, paneling, pipes, flooring. you are normally just better off taking a paint scrapper, or taking a razor blade from a utility knife and slowly scraping the stuff off.
BUT THE KEY IS, letting it fully cure, not the 2 hour initial cure, but full 7 day curing. if you do not. then the foam will still be "gummy" and "mushy" and will not be brittle enough to work with to clean it up.
needless to say, when i get it on my hands, it generally takes 4 to 6 hours to let it dry, then i just rub my hands together and majorty of it comes off. ((soap, water hot or cold doesn't work, just makes it worse and more sticky even longer)) and then over the next couple days rub my hands together a couple times and majorty if not all gone exception for were finger nails meets skin on my fingers. ((some times i have to let that stuff be and give it a week or 2 and let dead natural skin flake the stuff off))
on cloths, i may still have a spot were the foam was "discolored" but wearing normally ragged cloths when working with spray foam (learned lessons)
everything else for most part always cleans up with above. notations.
just never try to clean spray foam up when it is wet even if it is a little dap on something very important. let it dry first. and less likely to gum more area up and more likely to have it come off cleanly once it has fully cured.