My primary concern is internal seals, particularly the injection pump. The biofuel is indeed a very strong solvent. It will dissolve rubber parts in short order. My truck has no issues with it. I run 100% (B100) as often as possible. It runs quieter, smokes less, and the exhaust smells good. Depending on feedstock the biofuels can have a much higher gel point than petro diesel. Some of our fuel will start to thicken at 45 deg. f. You can blend it with petro diesel during the winter. I am making my own from waste cooking oil. It is a simple process but requires a lot of time and oil is getting difficult to acquire.
If you want to try biodiesel in a older vehicle you need to check for compatiblility with rubber parts. Also, if you want to try it in a late model vehicle under warranty you need to check with the mfr. due to all the emissions and computer stuff. But in general all diesels, being oil burners, love biodiesel which is just oil from another source.
My little Mitsu. tractor does have some external rubber fuel hoses. I think I will test those to see if they react to the fuel. I seem to remember a discussion about a tractor injection pump having internal copper compression seals rather than rubber. That would make sense but I need to verify that. The last thing I need to be doing is trying to rebuild an old injection pump. That little old tractor has turned out to be an invaluable workhorse around my small property.