I've been out of the pharm business for over a year now and from what I've seen the major rise in their cost basis is due to the marketing/sales required to be competitive. This doesn't add to the value of the compounds or treatments but does add to the corporate accounts under our current system. The system does respond to economic pressures eventually and some gov regulation is helpful. Unfortunately, we all pay higher prices. Worldwide price controls will mean that the US will be paying more for innovation/new treatments to keep the system rolling. No simple solutions.