With full acknowledgement to those who laugh at a .22 for self-defense, it is my very studied opinion that it is a formidable round, especially as .22WMR. Handgun fatality-by-caliber statistics are ample proof. Also IMHO, a very small .22 handgun is perfectly suitable for self-defense where the range is <15ft and having it
ON YOU and ready for rapid deployment is crucial.
That's why I carry a little NAA SA revolver every day. Concealable most anywhere. Right front pocket for me. Or at the TOP of the purse for females. There's even neck chain holsters.
North American Arms – Convenient, Reliable, Effective!
They are all SA; simplest (and IMHO safest) action. The standard birdshead grips are marginal for self-defense. Either buy the Black Widow model or buy some aftermarket oversized grips. Get both the .22LR and .22WMR cylinders (.22LR is much cheaper to practice with).
I like an old .38spcl J-frame or Ruger LC9S for keeping around the house. Wife SOMETIMES carries her LC9S in a Crossbreed mini-tuck IWB holster. She is most accurate with her CZ 75 D Compact, but that's getting too big for anything but purse carry.