We re-lamped the shop and office at work last spring. We found a number of existing fixtures that just simply didn't have the additional room for the screw in flourescents. In order to swap, we needed to change the entire fixture.
Some of our lighted areas' such as shop restrooms, parts storage area, and security lighting are on motion detectors. Flourescents aren't the best choice for constant off/on/off/on lighting due to slow starting. Better over the long haul just to leave them on during business hours. Flourescents in areas with constant off/on cycling didn't last any longer, and in some cases, not as long as conventional incandescent bulbs.
Also, in the entrance area, we had several banks of lights controlled by slide dimmers. Flourescents won't work with them.
Initial cost/estimated electrical savings/lifespan of bulbs considered, savings are no where near what the GE sales propaganda indicated, but we're saving SOME none the less.