The most effective way I know of to get rid of fire ants temporarily is Amdro. No permanent way to get rid of the little heathens though because sooner or later they will return on matter how hard you try to keep them away. If you have ever seen how they migrate then you know why they will come back.
I have seen the winged, migrating queens by the dozens on cars, asphalt, concrete and any other hard surface where they cannot blend in. Just last month I was at work and noticed a queen on the ground. I stomped her (with a smile on my face) and then I noticed another one. I stomped her, too. Then another, then another. Must have been about a dozen queens on the asphalt within a five square foot area. I guess that is why they spread so fast - they are hardy and oh, so prolific. I don't know if the queens surface and migrate on some sort of schdule but it seems when I find one I will always find several more in the immediate area if I look around.
Several years ago I found about twenty of the she devils on the hood of my car, which was sitting in the noonday sun. Apparently they, had flown/were blown by the wind and had the misfortune of landing on the hot, metal surface which was at least 100 degrees (mid-summer.) They got fried as soon as they landed. (Diabolical laughter appropriate at this time!)
Now the FUNNEST way to get rid of fire ants is whatever way I feel will inflict the most pain and damage. I have doused their nests with boiling water, gasoline, motor oil and bug spray. I have pushed my mower over their mound, chopping the top of the nest off w/ the blade and then left the mower sitting over the mound, hopefully sucking up, dispersing and chopping up as many of them as I can as they pour out of the ground. I have flooded them with the water hose just to get the satisfaction of watching their eggs surface and be washed away. I have ground their nests up with my garden tiller. I have burned them with the smoldering leftover coals my my b-b-que pit. Hmmm. Did I leave anything out?
Sound like too much enjoyment? Maybe so! I give them paybacks every chance I get for the stinging, burning blisters they inflict upon my ankles and legs.
I read somewhere that humans do not develop any immunity from fireant stings. Supposedly, quite the opposite happens. The more one gets stung/bit in a lifetime, the worse that person's reactions will be to the sting/bite. I say stung/bit because the miserable little beasts bite you with their mouth and then double up and sting you with the other end. That is why they appear to be balled up when you find one attacking your leg. Kinda of a double whammy. Is it any wonder I like to return the favor with as much pain and suffering as I can?
Fire ants. The insect you love to hate.