When I'm following GPS directions, I have it so it's always looking in the direction of travel. When I'm just driving along, I also have it looking in the direction of travel. It tells me what road is coming up next. Works great if you're looking for a passing zone ahead, too. But if I want to zoom out to see where I am in an area, I want it oriented at North is up.
So what other things do you like the GPS to display for you?
In my older cars that don't have a compass, I have the compass displayed. I have time to destination up if I'm following directions to a specific location. I'll put up miles to destination, too. In hilly country I pop up the elevation. I rarely use the speedometer view, unless I have the phone sitting on the dash in front of the speedometer.