Red,
For many years I've designed radiant systems with thin slabs over a standard subfloor. These have, in the bathrooms, tubing spaced on 6" centers. So the response is felt in minutes, instead of hours. It also means the cool down times are less and so, less overshoot. It also means that room thermostats have little value, but timing becomes more important, at least in the bathrooms and kitchen.
In my home I went the opposite direction to bring the floor temp up to just below where I might want it on average and then add some heat as needed. The 8" slab becomes a stabilizing factor and energy storage mass for solar. But even with this large mass, zoning allows a reasonable response time if the energy available is high enough.
In the Bay Area, in CA the heat loss I use is seven BTU/ sq. ft for a break even number. Ten BTUs will run a house OK, but the response is poor. Twenty-five works well even with one thermostat zone in the whole house, but when you have multiple zones, you might have 100 BTU/sq ft available or more for a given small zone. Then timing those zones with priority to lifestyle, such as warm bath at 7AM and warm living room at 6 PM, you can get excellent response. In those cases, "warm" does not mean the wall thermostat is satisfied, it means the floor feels warm and the air temp is relatively cool. It also means the boiler is not overloaded on small zones and can feed a given temp during the whole cycle. This gives excellent response and predicability. A delivery temp of 126 degrees instead of simply a few degrees per pass makes a big difference, even though the few degrees per pass will do the job eventually. And again, the room thermostat is an extremely poor way to run most systems. It only acts as a rough high limit that causes overshoot, especially in smaller zones.
I found a neighborhood with 756 homes that have radiant heat. They were built from the mid '50s to the mid '60s. All were set up the same with a 100,000 BTU boiler and one thermostat. Almost everyone I've talked to has the same complaint. Uneven heat, overshoot, high bills, cold rooms.
I can go into virtually any one of them and do the following: Even out the heat in all rooms, reduce the heating bill by at least $100.per month and eliminate the overshoot, which makes them far more comfortable. This is all done by improving the circulation rate, balancing the manifold, tuning up the boiler and installing a setback thermostat. Then I help them see how to re-think the heating process and realize that the thermostat is a poor measurement of comfort. Universally, they ALL praise the outcome of this process.