Every trailer I've ever been around has it's own "personality". There's always one set of tires that wear different than the other. When you're turning, you drag (either front pair or rear) one set sideways, since they don't turn with the steering. My 25' gooseneck wears the front pair about 25% faster than the rears. All I can offer is to try rotating the tires every few thousand miles. See if that has any effect.
Single axle brakes will work, provided that axle has the same (or more) weight loaded on it as the other axle. Even with "walking beam axles", that doesn't always happen according to plan. Should the brakes end up on a "light" axle, you'll be dragging them, especially when the trailer is towed empty.
One more bit of advice, based on my experience (and opinion for whatever that's worth) is to adjust the brake bias down when towing a light load or empty trailer. I've seen many an empty trailer smoking the tires when the driver comes to a stop. That leads to flat-spotting the tires, which makes them "bounce" instead of rolling smoothly. A bouncing tire can't make good contact for the next braking. (Shock absorbers on a trailer would HELP correct some of this)
And from a couple bad experiences, trailer tires need to be replaced when they start showing uneven wear. They take a thrashing.
Signs of grease around a trailer brake hub might indicate a failing seal, or come from over-filling hub with wheel bearing grease. Electric brakes do generate quite a bit of heat. (Especially in "city driving")
Don't ignore signs of an impending problem with a trailers wheels, tires, axles, or brakes. It's trying to tell you something isn't right.