As a longtime GC, I would say absolutely you 'can' run a project as an Owner/Builder. The hardest part as mentioned is getting and running the subs. But it depends on the level of quality you desire as well. There is no way you can achieve the level of quality that a GC with years of experience can produce. No way.
I've personally never seen a Owner/Builder home come out very well, and I can walk through and pick to pieces all the errors and mistakes....but if you just want a 'kinda good' house (which most people are frankly ok with) then you will be fine.
And if you're doing this for the experience, that's great, but if you're thinking you will save that 20%, you're probably gonna be very disappointed. Too many moving parts you will miss, and time is money....... plus the subs will take advantage of you and you have no way to catch it....