I have no doubt that some people do feel better when they put in a portable air cleaner, and bottom line, I guess that's what you're paying for.
However, you have a couple of issues that the portable air cleaner have no control over, particularly in a residential household, the primary issue of air rotation.
Best bang for the buck? IMHO a 5" MERV 10 or 13 media air cleaner in your duct system.
Then you have the dust mite issue which some people are allergic to. Problem is, most people think it's the temperature that eliminates them, it isn't, it's the RH (which temperature can play a role in).
Ever notice that most portable room air cleaners are not made by major residential/commerical IAQ HVAC manufacturers? There is a reason for that. However, I can assure you, some of them (IAQ manufacturers) are kicking themselves in the head for not jumping on the marketing "bandwagon" (there is a HUGE market in portable room air cleaners).
Ironically enough, some of those same manufacturers who make portable electric heaters also make portable room air cleaners.
Guess we'll have to agree to disagree
Going that route (mulitple units), spend the money and get a whole house dehumidifier and add an outdoor fresh air intake or go with a residential energy recovery ventilator, added with that MERV 10 media air filter. That's assuming you have a decent duct system.