The 6.4 is the powerhouse of the diesel engine world, Cummins and duramax can even begin to touch it. The engine is basically the 6.0 bottom end (super strong) with a common rail fuel system that has a twin sequential turbo. With the EGR and DPF removed and a tune added to make it work, it is a super work horse. Even the new 6.7 can't run with a well put together 6.4.
The problem is, it takes some money to get it reliable. The fuel system does not like water in the fuel, and just a little water can take out the fuel system. The rocker arms tend to wear out around the 100k mile mark, so keep that in mind. If it isn't deleted, the DPF is burned off by overfueling cylinders 7 & 8 to send unburnt diesel to the DPF to burn off the gunk. This causes the oil to become diluted with diesel fuel and destroys the oil in about 3,000 miles. Again, just delete it and save yourself the worries. It does have the tried and true transmission in it, so no worries there.
I personally like the 6.4 and the styling of that generation. My dad had a few in his construction truck fleet that held up real well. Our head diesel mechanic deleted them though and they received fluid maintenance every winter. The 6.4 were the trucks to haul the heaviest of loads they had. They did well...