... except some of the screw are backing out.
Could you clarify whether the screws were installed on the ridges of the metal (the part of the metal that sticks up in the air like a little hat), or in the field of the metal (the part that's tight against the purlins).
I've never accepted that the screws were literally being turned counterclockwise and backed out. I've imagined lots of possibilties to make it look like the screw backs out, a few might suggest some investigation on your part before doing a replacement:
1. Screws were not installed correctly and either stripped the wood or hit a weak spot in the wood, so the are being pulled out rather than backed out. Contractors who predrill panels on the ground minimize this problem.
2. Screws weren't put in all the way to begin with (hit a knot for example), so as hole in metal wears and becomes loose, the screw now appears to have backed out.
3. Thermal expansion of metal could cause the screw holes to become egg shaped as the panels try to move along the plane of the roof due to thermal cycle. This might cause the screw to appear loose without it actually backing out.
4. Moisture in the attic space allows a freezing/thawing cycle of some kind between the metal and purlin that pulls the screw out of it's threaded hole, again causing it to appear to have backed out (not sure I even buy that argument). Moisture variation might also affect ability of wood to hold the screw.
I'd make sure the air space under the panels is properly vented.
If I lived in an area of extreme day/night thermal cycling (like New Mexico or places in the south), I might consider putting the screws in the ridges instead of the field. I know people carry their crosses into a holy war over field vs ridge, but it seems like putting screws in the ridges is much more forgiving of metal that slides around a lot.