Have had seven different sets of nitto's and each got about 45000-60000 miles a set. Great traction and no road noise. Ran them on two 2500hd diesel and one 3500hd Dually. All 285/70 load E
I have a 2008 2500 Duramax with 150,000 miles on it and just took off a set of the Nitto's and was not impressed. Not even 30,000 miles on them and they are wore out. When new they were fine- had good traction, low noise, etc. But they need to last a lot longer to be considered a good tire by me.
I now have the Cooper Discovery AT3's. I think the sidewall's are a little soft, as the truck tends to "roll" a little bit more when towing, but they have great traction, nice tread, ride great and are quiet. They are also one of the few LT tires with a warranty- 55,000 miles. We will see how long they last.
Other tires I've had on this truck: BFG AT's- great tire wear, but poor winter traction, ride & noise.
Bridgestone Duelers- ok tire wear, ok traction, ok noise. Probably the best all around tire I've tried, but still only got around 40,000 miles on them.