I've been using both for many years in radiant heating systems. They both work well.
You don't say if you are looking for drinking water PEX or radiant heating PEX. If it's drinking water PEX, look for an NSF-61 rating on the tubing.
Don't sweat the small difference in flexibility as anything that might make the job harder or easier.
If you use PEX, think in PEX and bend it around corners or pull it through areas instead of using a bunch of fitting as you would with copper. Avoid Sharkbite fittings. They work OK, but are not the quality of the crimp ring system. I would never put Sharkbites where I could not get back to them easily. To me they are just a way to get by without much skill, but not the best way.