When E-10 sits and sometimes even when it's supposedly fresh at the pump, it begins phase separation, as mentioned on the Startron gas treatment bottle posted further up this thread. Phase separation is the components of E-10 breaking down, and results in the water in the gas to settle to the bottom of the tank. Water and combustion in gas engines simply don't mix. Additionally, for chainsaws and things that require gas AND oil mixed together the oil also separates out from the gas and causes additional lubrication/combustion issues in 2 stroke engines. So, at the end of the day, when one let's their can/container of E-10 mixed with 2 stroke oil sit for weeks, or months and then goes to use it - does the operator shake the container vigorously BEFORE adding the mix to the saw, and then shake the saw also to mix further with the remaining fuel already in the saw's tank? I doubt it. It is now stated in some recent owner's manuals to do exactly that, remix the mix by vigorously shaking the container prior to refueling.
So most are using gas, if E-10, that has poor mixture of needed oil, as required, and quite likely a watered down mix as well. Not a good combination for the saw's engine or operability.
Additionally, today most plastic fuel containers no longer have vents on them. This is because with no air vent there is less chance of additional air getting into the container while in storage. This is a relatively new design and comes from the need to keep E-10 from absorbing more atmospheric moisture than it already contains when at the pump. And to keep gas fumes from entering the atmosphere that we all breath, even conservatives!
So why bother with all the possible downsides of E-10, IF one can access NON-E-10 fuel, then I say go for it. I know I do. I drive over to NYS to get my E0 gas and use it in everything that takes gas. 2 stroke, 4 stroke, etc. I also put half the container of Stihl's ultra oil in the gas container then fill halfway and close it,shake it up, then fill it the rest of the way and shake to mix the mix again. When using the mix gas I shake it before filling the saw, and then the saw, as described earlier. I never leave the top off any container of gas. I see landscapers and loggers and everyone driving their pickups around with the old vented gas containers with the spout in the ready to pour position and wonder how their equipment runs?!:confused3:

YMMV, but I don't do the drain everything I own routine- I can't justify the time for little to no benefit.
And if one can't find E0 in a reasonable distance, then by all means buy the quart sized lab grade gas for usurious prices...