You need a design that will be efficient before you fabricate anything. I'm not an expert, but my brother is an HVAC contractor in California. The first step is to do a load analysis to determine the proper size unit and then you need the whole duct system sized to accomodate the unit and proper flow in each zone or room. This will relate to CFM of the air handler, static pressures, the duct type, size in length and width, number of turns, etc. An improperly designed duct system will result in high operating costs, stress on the the compressor for an air conditioner or heat pump if your using one, rooms that are constantly too hot or too cold, and excessive air noise. According to my brother, money spent now for an engineer will be more than returned in future energy costs, durability, and comfort.
I had a house built on the east coast by a contractor and my brother happened to be visiting at the time. My brother looked at the ducting as it was being installed and said it was not designed properly. The general contractor called the HVAC contractor who conceeded that it was not designed and sized right and they ripped out the whole main duct and redid it. The second one they installed was improved, but still not correct so they redid it a third time. If I had to grade it, the first try was an F, the second a D, and the final a C+. This was an HVAC contractor that had been in business for 25 years and, according to the general, had a good reputation.
There is a calculator tool for duct design used in the trade called a "Ductulator". Several companies make them, but according to my brother, Trane is one that is used a lot. My brother said the Ductulator is not for use by the layman. I'd find an engineer that knows how to use a Ductulator.