1) where the house slab/foundation is going to go, hire a good bulldozer guy to push the trees over. This takes out almost everything of the root ball so that there are not long-term settlement issues as root balls gradually decay. Although you may be able to do this yourself with the big backhoe, a guy with an appropriately-sized dozer can do it so much faster and with no wear an tear on your equipment. The guy that did ours cleared the home site, yard, septic field, and back driveway about 100 yds long, and pushed it all up in a very tight/neat burn pile in a little over one day.
2) Assuming that you will need septic, make sure you identify and clear a sufficient area for the drain field and that there is sufficient "perkable" soil! We had to alter our preferred house location a good bit to have it near a suitable area for the septic field. And had to hire local soil scientists to confirm all that before the county would grant a septic permit.
3) If you are out in the middle of nowhere like we are, determine a suitable position where you can get line-of-sight from a satelite dish to the satelite, and clear any trees that are in the way!