I have the new 6.7L Powerstroke. So far no complaints with the DEF system. I expect to go 7-8k miles before having to refill, so it's not that often, and is easy to find. Don't really have a choice on the new pickups.
It is another bunch of "stuff" added to the tractor, so I might take that into consideration when looking at a new machine if not all manufacturers were doing it, since most of us keep our tractors long past the warranty period. Although I don't have complaints about the system on my truck as of yet, I'm not sure I'd be too excited about having to deal with it on my tractor, until there was no other choice in the matter.
Smaller diesels can still get by without the DEF system. The DEF system is all about getting more power with better fuel economy & cleaner emissions than comparable non-DEF engines, and becomes more beneficial as the engine size and power levels increase.
It appears as if it is the wave of the future, at least at this point, and EGR systems do have the occasional issue with sensors. As to which version is better? I guess maybe the one with the least amount of components that could break.
By the way, the Ford DEF tank is 8 gallons as I understand it, not 5.