I would doubt if it is the refrigerant, if the unit was designed properly and the components are working correctly, it should run smooth, one may be able to hear the refrigerant at times when the compressor shuts down as it equalizes between the high and low sides, of the cooling circuit,
and most likely the refrigerant is or has some hydrocarbon refrigerant in it, (it is my understanding most of the world uses hydrocarbon refrigerants), a mixture of propane and butane will be nearly identical to the R12, propane is nearly identical to R 22, propane is called R600 when used as a refrigerant,
the hydrocarbon refrigerants run just a smooth as the other refrigerants, and most of time with more efficiency and can move more heat, all a refrigerant is a gas that can be compressed in to a liquid, some at lesser pressures and some at greater pressures, which usually make them better for various temperatures ranges.
a hydrocarbon refrigerant is not dangerous as long as there is no oxygen present in the system, hydrocarbons are or were used for pressurized spray cans, no one seem concerned to have a can of flammable substance on the shelf, a gas tank full of 20 gallons of gasoline in there car, and people do ont get excited with there gas piping to the furnace or hot water heater,
yes if a massive leak occurs and flame is present, it could add to the flame, but most leaks in a refrigerant system is a slow pin hole leak that in most instances the leakage is such that to obtain an explosive mix with air is very unlikely,