If the emissions was kept on, and you never kept up on maintenancethe lifters would need replaced around then. Otherwise no. The blocks on the 6.0 and 6.4 are basically the same expect for some extra holes in the 6.4. The bottom ends do not wear out at 150k, in fact very few of those blocks ever had a piston hanging out the side even with crazy boost. They were designed for medium duty school buses with a super huge bed plate. The VT365, or Ford 6.0 was built for school busses and was in hundreds of thousands, the key was with no emissions. It ran fine.
However, as a point of reference...there are plenty of 6.4 that are deleted and are running fine today. It turns off the dumping of fuel on the exhaust stroke, among other things. Diesels run amazing with no emissions, they're not that complicated.
The EPA had strict emission changes in 2003, 2008, 2011. It doesn't take a rocket scientist to see manufactures had to completely go to new engines to meet those standards, the flow chart is: EGR (6.0)>EGR+DPF+COMMON RAIL (6.4)>EGR+DPF+SCR+Common Rail (6.7). There was too much engine infrastructure change needed and it was easier to just design a new motor.
To the point of needing to run wide open to keep every thing clean, well that was a huge issue for all of them early on. The pressure switches would cake up with carbon from lack of running hard and do weird things. I know there was a time Ford on the 6.7 turned off their inputs in the tuning because they could not get enough pressure switch's to prevent the truck from going into limp mode. It's no longer an issue and they learned good and hard.
So to say it's a 150k motor...well I disagree. But Heydue is a data point in your favor.