We have a 2001 F250 short bed, extended cab with around 105,000 miles. Don't remember the rear-end on it though. I believe it is a 4.10 though. My wife gets right at 20 mpg with the truck. I get closer to 18 mpg. If the mileage starts to drop, it is a good bet the air filter needs changing.
Hauling is a different story. Depending on the load and terrain it will be anywhere from 16 mpg to 10 mpg. Our loads rarely get much above 8,000 lbs and the trips are usually under 400 miles round trip. There have been a couple 2,000 mile round trips, but those were lighter loads. Probably around 5,000 to 6,000 lbs.
With our current uses, we expect many, many more miles out of our truck. /forums/images/graemlins/grin.gif