OK, now that have some replies, here are the numbers. Three trips to my parents' home, empty: best average going down among the three 19.2 mpg by computer; 18.8 by hand calculation at 70-74 mph average speed (approximately). Coming back (more long uphills) 16.8 mpg by computer, 16.7 by hand calculation. Same average setting on cruise. Loaded once to parents place recently with a lot of mountainous uphil pulling close to 8000#, 11.8 by computer; 11.0 by hand. These readings have each been obtained with between 2500 and 3000 miles on the odometer, they were NOT this good for the first 2500 miles (on average 2+ less). Truck is a crew cab F250 with 6.4L and MFWD, 3.73:1 rear axle ratio. I really did not feel I could equal the mileage of my old truck, and I have not yet, but it is coming pretty close and now has only about 3500 miles on it right now. This is WITH the emissions equipment mounted. I realize some other might get better numbers, some not as good, but I think that some of the low readings noted by other posts on the 6.4L might be those with more aggressive gear ratios than I have on my truck.
John M
John M