Come on down south....maybe not in July or August. A great trip, which I do every few years, is Memphis to New Orleans. Drive down highway 61 all the way. Stop in the blues towns in Mississippi. Try the famous tamales and go to Ground Zero blues club in Clarksdale (1 hour south of Memphis) which is owned by Morgan Freeman. Looks like a real dive, even a little scary, but it isn't...it is tourist friendly. Memphis is great. New Orleans is, well, New Orleans. If you like food and music a trip down highway 61 is hard to beat. In the delta, between Memphis and N.O., it is pure Mississippi, which means agriculture and poverty but the area is beautiful. Stop in Vicksburg with its downtown on the river and its huge Civil War battlefield and recovered iron clad. If you need recommendations on where to eat in N.O......or Clarksdale, Vicksburg or.... just send me a P.M.
If the deep south on the east coast is more your speed, start in the Myrtle Beach/Georgetown area. Go to Brookgreen Gardens in Georgetown, one of my favorite places on earth, head down to Charleston and from there to Beaufort, Savannah and St. Augustine. That's a trip that is hard to beat. Used to live in Charleston myself. Probably one of the top five food cities in the US.