Have used slime in several tires - everything from smaller mower tires to front wheel tractor tires - backs would take a lot, but would try it. Had a couple bigger holes that it wouldnt work on, so I also keep a plug kit handy.
We live away out from town, so if I had to take a tire off, take it into town, lose the time, etc for every flat, it would add up. Is nice to deflate the tire, pump some slime in it, then air it back up and good to go...
Of course, I never find the flat except when I need the equipment, so is nice to fix and get to work...