The mileage will depend GREATLY on terrain. From my personal experience, the more gears a transmission has, the more it "hunts" for the right gear in the hills, and that is far harder on a transmission, that a lower rear axle ratio ever will be. About 90% of transmission wear is caused during shifting, the more it shifts, either up or down, the more it wears.
Taller (smaller numerical number) axle gearing is ONLY beneficial for mileage on fairly level terrain and steady speeds. That is the reason most are going for this, and that is due to ever tightening and ludicrous (IMHO) EPA standards for CAFE. I have changed rear axle gears from 3.42 to 4.10 for towing and I could ABSOLUTELY tell the difference. I seriously lost only 1 MPG and the difference when climbing grades was night and day. This is especially true with smaller vehicles and gas engines. Diesels can get away with taller gearing because of their torque, but gas engines have much less torque and usually less RPM range where it's available.
Towing is more then getting a trailer rolling, it's having the power available to keep it rolling on steep grades too.