Some of them time when a tire comes off it is because the wheel bearing seizes and then it cuts the spindle then you have the complete set of duals, hub and brake drum which on a semi is more than 200lbs. I saw the after math of just that in the 1980's it hit a Cadillac head-on and pushed the engine into the passenger compartment.
I had that happen on an F550 service truck. Was heading down a toll road on my way into work. Was fixing to merge onto another toll road. Toll road had three merge lanes. Right side was west bound only. Lane I was in had the option of going east or west.
I felt the truck catch and veer to the right, then started wobbling on that side. Thought I had a blow out. Checked the mirror on that side fixing to merge over to the brake down lane when I saw a tire pass me


. Let out a couple cuss words, straightened the truck back up and took the east bound brake down lane.
As I was easing the truck to a stop, I watched the tire weave through traffic and merge west bound. After getting stopped, I checked the truck out. One of the right real wheels was what went by me. The other finally flopped over when I stopped. And the axle, and rotor were resting on the tire like someone jacked the truck up and placed the wheel under it.
After the tow truck got there and loaded my truck, my boss and I went hunting for the other tire. We found it almost a mile down the road and about 20ft off the road in the grass next to a retention pond.
In my case, the shop that did the annual DOT inspection the day before on the truck overtightened the lug nuts and stretched the threads really bad causing the rims on the right rear to wobble slightly finally causing the studs to give out. Said shop had to pay for the tow, and the dealership for the repairs. They ended up having to replace all 4 rear rims, a new hub, as well as new studs and lug nuts on the front axle and left rear.
Thankfully the rim and tire somehow got through traffic without hitting anyone.