It was a huge pain. My original plan was to route the 3/0 copper through the opening between the meter base the the right panel. But once I got the old feeder removed from the meter base, I realized there was no conduit in the wall between the meter base and panel on the inside. So I then had to unbolt the inside panel as was the bared able to get to the set screws on the 2" clamp on the back. Once I got that loose, I was able to pull the old feeder through from the inside. I was lucky that the clamp on the meter base was not tight and I was able to pull the feeder through, although I had to pull on it hard to get it to go. Once I got it out, I mounted the panel to the wall again and installed a 2" plug in the hole.
I thought about installing a 2" conduit pipe in the wall between the meter base and panel, but after pulling out the old feeder, I realized that the existing hole was not 2" diameter but rather 3 smaller holes drilled next to each other, just large enough for that original feeder wire. So I had to get rent a core bit and drill and drilled a 2 5/8" hole in a new location, and then installed my 2" conduit for the new feeder wires to run through.