Pfft.
The only possible issue is the gun won't eject the fired casing.
I've used a few in one of my .45 1911's, and there isn't enough inertia energy to blow the slide back all the way to cycle the spent casing out and pick up a new round out of the magazine.
That's no big deal at all once you're aware of it. Just cycle the slide manually between shots and it's fine.
I've used the 45 acp snake shot loads a few time for snakes, and it will put them down hard. You just have to be very close, I agree that 5 yards is about max to ensure pattern and energy. I used the 357 mag snake shot loads a few times as well. They don't perform any better or give you any more usable distance. The only advantage for the revolver is you don't have to manually cycle the slide between shots.