With 8000 white pine and tamarack in the ground over the last few years I have had some practice with Roundup. The backpack sprayer and plastic-pail-with-bottom-cut-out-on-a-handle approach works well if you are young and there aren't too many to do. For long runs, though, an electric sprayer in the back of my Polaris Ranger running off the accessory power and a wand on a 15' hose works better. Princess Auto sells a dandy for about a hundred dollars. The downside is that someone needs to drive the Ranger.
I use about a 3% solution and take great care to keep drips off the little trees, especially walnut seedlings.
Last year I put 14 hours on the Ranger spraying with this rig. It went well, though I still mow around the trees. Roundup won't last the season in Eastern Ontario; the second application worked through to now, though. I'll need to get at them in the next two weeks.
My equipment-savvy neighbour took a look at my setup and promptly bought a copy of the sprayer to use on his friend's Ranger.