I will take the .223 over a 22-250 any day.
The last time I bought ammo it was $6 for a box of 20. That is because it is a military caliber and there is economy of scale in making it. With the current ammo shortage I can't find any to buy so I don't know current prices.
For every 400 yard shot I get a chance at, there are 25 or 30 200 yard shots, and an equal number under 100 yards.
Same thing for a deer rifle. I use a .308 and my ammo is $14-15 for 20 rounds. A lot of the people I hunt with think you can't kill a deer with anything less than a .300 WSM at $40-45 per box. I don't think you can sight in the rifle with less than 20 rounds, maybe more. They solve that problem by not practicing and not sighting in.
I have yet to miss a deer for lack of power in the cartridge. I have missed because they stepped behind a tree, ran behind a tree, or ran into the next county.
Your post prompted me to check on current ammo prices, as i have not done so in a while.
While you can buy military surplus ammo for the .223 and really cheap prices, I have not had much luck with the accuracy of said ammo.
I checked on cabelas for winchester ballistic silvertip bullets, which is simmilar to what I shoot, and both the .223 and 22-250 are 23.99 per box. Which is $1.20 per round. This reminded me why I reload, besides finding the optimum round for my gun.
Currently I load the 55gr combined technologies ballistic silver tip bullets with 26.5gr of varget powder, which is basically the ballistic silvertip bullets.
At current prices of
21.99 per lb of powder
21.99 per 100 bullets
2.99 per 1000 primers
21.99 per 100 .223brass
34.99 per 100 .22-250 brass
figuring about 5 rounds per brass I can load
.223 for .37 per round and $7.40 per box
.22-250 for .43 per round and 8.60 per box.
I quote the 22-250 because I used to shoot one and my dad still does so we still load for them.
the reason why i am bringing this up is anyone who shoots a lot of centerfire cartridges, it is worthwhile to spend about $300 on a reloading press. Then for each different caliber you want to reload, it only cost $30 for the dies. Our press has paid for it many times over as we reload for everything, .357/.38special, .223, .22-250, 6mm rem, .270, and .30-30. With a savings of about $16 per box of ammo, it doesn't take long to pay for the loader.