Surprisingly, you'd get used to it.
When I was a kid, we lived right next to the main flightpath of the airport. And today not much further. We just don't notice it anymore. When our cousins would visit from Cincinnati, they'd complain about the noise. Then we'd visit them, and they lived across the street from a major B&O railroad line on the north side of town. We'd complain about the noise.
As for some young people starting out, I'd say those homes aren't in bad shape, and are cheaper than a car. You're at work all day. The trains would lull you to sleep.... until they blew the horn!

But you'd get used to it.