Just to put those fees in perspective, think about this. It is generally agreed that once you retire, you can draw down your investments by 4% per year (adjusted for inflation yearly). This 4% includes everything - taxes, health care, and any fees you pay on your investments.
So on a million dollar portfolio, you have $40,000 before taxes. Now if you pay 2% fees on your investments, you have given away half of your income - $20,000. As a comparison, I have investments in Vanguard Admiral Total Stock Market shares where I pay 0.07% (not a typo).
On the other end, when you are in the accumulating phase, these fees compound against you, as has been noted by others, decreasing your end portfolio by ten of thousands of dollars.
So investing where there are low fees really is a big deal.