Colorado bases registration on manufacturer's cost, vehicle type, weight, and model year. Figure 2% of the manufacturer's cost the first year you own the vehicle (e.g. $1,000 on a $50,000 vehicle), then it slowly drops to a fixed rate. Here you are penalized for buying a new vehicle with high license fees. Then our glorious former governor Ritter tacked on another $40 per year "fee" for all vehicles to pay for roads. Well our roads are still just as crappy as ever.
Oh, and don't forget the $10 per vehicle E-470 fee for us in the E-470 zone. E-470 is a PRIVATE toll road! That ripoff from end to end costs about $25 one way as I recall for the 25 - 30 mile trip. Heaven help you if you have more than 2-axles as they'll really stick it to you. This toll road is mostly empty because it costs so much to drive on it, and I won't use it due to the cost.
Then add into the mix the biannual emissions test at $25 a pop for some areas along the Front Range.
Factor in state and federal fuel taxes, and you get to bend over big time here.