I'm considering the purchase of a .380 (keltec P3-AT, LCP or the Taurus TCP 738 - any opinions on those?), primarily because I would be planning for pocket carry (inside a pocket holster). The main reason for this is comfort, and as many have said, a .380 on you is better than a .45 at home. I see a tremendous number of folks that are (I believe) attempting to carry concealed using a waistband holster around the small of their back. I say I think they are trying to carry concealed because it is tucked into their pants and their shirt is over it, but it plainly "prints" through, or is visible as they move around, bend over, etc. I would rather not have my carry gun so visible. A lot of the times in the summer (and many days in the spring and fall), I'm wearing jeans and a T-shift, so pocket carry would be easiest year-round.
I've also seen some Sneaky Pete belt holsters that look like PDA/smartphone cases. I like that idea from a comfort standpoint, again, but I'm not sure about it from a security standpoint. Anybody have any opinion on those?
I'm also in the camp that I feel that if a .22 is all you want to carry, I'm all for it. I personally don't want to get shot with anything, be it a .22, .380 or .45.
Our instructor, whom I thought did a very good job, said that the best thing you can do is to remove yourself from any situation where you feel threatened without drawing your weapon, if at all possible. If you can't, then you should only draw as a last resort, because in all likelihood, your life will change for the worse no matter what the outcome of the encounter is.
Good luck and take care.