I have used both and can say a 2WD tractor turns and handles better than a 4WD tractor that is in 2WD.
I don't have a comparable 2WD tractor to compare, but my 4WD tractor turns and handles much better in 4WD then in 2WD. But I suppose you are talking about level ground, and the biggest level spot on my property is the parking area in front of my garage.
Plus running a 4wd in 2wd shouldn't wear the front drivetrain at all.
Maybe not as much as in 4WD since the front drive train isn't under load, but unless you have unlocking front hubs (which I've never seen on a tractor) all the front drive parts are moving either way.
Terry