As a lefty, I have all the lefty issues with weapons made for right-handed people limiting my choices. Even so, I prefer full size frames with ambidextrous safeties and slide catches I can operate with my pointer finger or left thumb. I also like the pistol grip angle of .45 ACP but do not own a .45 ACP. For those reasons, I settled on M&Ps. I hate the M&P trigger however and either have done my own trigger jobs or popped in aftermarket Apex triggers to get rid of the M&P trigger creep, an issue that for me, due to soft tissue damage, really effects my accuracy.