My brother has a toyota pickup I believe around a 2007. Still has less than 100k. Last thanksgiving it broke down in Sheridan Wyoming. Some issue that ended up being covered by Toyota but he had to leave it there and my Mom drove him and his wife back to Bozeman and then back to SHeridan to get the truck a few days later.. When he got back he had another check engine light and it turns out there is a crack in the exhaust manifold. Not a major issue so he is going to run it like it is but still frustrating. And he also gets 12-14 MPG most of the time.
I give him lots of chit as his truck is pampered, lives in the garage, never hauls anything, etc.. and mine of the same year has 4x the miles, weighs nearly twice as much, stays outside, pulls heavy loads regularly, running dirt roads all the time, breaks down less, and gets much better mileage.
The only brand I have really never heard of people having issues with is Subaru.