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Orthene or its base (acephate) is without a doubt the quickest way to destroy fire ants, it will kill the mound typically within 24-72 hours, only requires about a tablespoon per mound. It stinks all to be damned but I have never seen anything kill them as quickly, or fully as it does. Down side is dogs that like stinky stuff may be attracted to it as well
	
		
			
		
		
	
				
			 
 
		 
 
		 
 
		 
 
		