There are some studies out there that it's more efficient to heat and cool the entire envelope of a house instead of just the living area. This includes the attic space. This is done with spray foam insulation, and you have to make it really air tight to work. Then it's easier to maintain the temperature inside this envelope then overcoming the extreme heat that comes from the attic space. Another advantage to having the entire house sealed is that there is no access points for fire to get into your attic area, and under your roof since there are not vents. This was discovered during one of the huge fire storms in Southern California.
It's a huge upfront cost, and I don't think it's worth the expense for a barn or workshop.
I personally feel your best return on what you spend is to get R60 in the attic, have excellent air flow from your eaves to your peak, and seal the walls so no air can get through them. Heat goes up and down, so attic insulation is huge. Air flows side to side, so stopping it from defeating your wall insulation is also huge.
Some recent studies that I've read are finding that instead of house wrap, you can improve your efficiency significantly by painting the entire shell of the house, the OSB or Plywood, with a polymer type of waterproofing paint. ZIP System comes with this already applied, and then you use their special tape to seal the seams. By painting it on 100% of the exterior shell, you get an even better seal then ZIP System. In extreme environments, this has proven to be a significant improvement with measurable results.