I don't know about an R22 system I have changed over an older R12 and a 123 system to "R290";
The one 134 system I used cans labeled R290 it lost most of the oil so I added a 134 compatible oil
and the R290 and that system cools better then it ever did.
The older R12 system was one that had a small leak and it would cut out on low pressure every spring when we started it up,
I just started topping that one off a 20# bottle, turning it upside down to get liquid I did it for 3 years running and it is one of the coldest cab tractors we run now. I haven't done it this year yet, because it's still working good.
As far as an explosion hazard, get real, how much is in the refrigeration system. Certainly not enough to be a major hazard with a slow leak.
Dissipation in the air will have it in a non flammable concentration almost instantly.