I don't remember how we got down this rabbit hole. Chances are though, that everybody is right and everybody is wrong.I'm not an authority on human gunshot wounds but have dealt a fair number to animals and never noticed the ricochet effect. As horrific as it sounds, ricocheting off a bone would be much preferred to smashing the bone, mushrooming so that projectile is more damaging to soft tissue. Anyone that has fired many 22 rimfires is familiar with the distinct sound made by projectiles after ricocheting.
A 22 cal fired from centerfire 22-250 often explode on impact instead of ricocheting and even when it ricochets, the muzzle blast and sound from impact drown's the sound of projectile traveling. Manys a savvy gun owners have relied on their little 22 rimfire to frighten the bejeebers out of would be trespassers and burglars when they had far heavier artillery in the closet. The larger number of 22 rimfire wounds when compared to others is because more are fired at people than others and lack of respect results in more accidental shootings. Eventhough first responders and emergency rooms see more 22 rimfire wounds,I think they will say most other gunshots are far more serious.
More than many are interested in hearing and less romantic than lore but there you are.
Bigger is useless until you hit your target.
I will say this; For a while I burned 20 rounds per night, 6 days a week through my Mark II. On Sunday I would practice with my GP100. I've killed a lot of milk jugs and paper plates with the various .357s I've owned over the years.
I've killed a lot of small game and the occasional coyote with my .22 handguns in various configurations. In my younger days I would stop buying meat on Oct 1 when grouse season started, and deign not to start again until January 1. (In years when I didn't tag a deer I was some happy to welcome the New Year... there's only so many ways to cook a grouse.
I hope that it never happens but if I ever need to defend myself I will reach for the gun which I am most familiar with, although if time permits it will be backup for my 12 gauge.
There's an old adage; "Beware of the man who only owns one gun, because he knows how to use it."