IslandTractor
Super Star Member
- Joined
- Sep 15, 2005
- Messages
- 15,802
- Location
- Prudence Island, RI
- Tractor
- 2007 Kioti DK40se HST, Woods BH
Good post sir.
The issue we face is we do not have 50 years to "solve" this. Currently our peak is estimated to be in a few weeks.
I have no idea how to structure a "good" test. I presume the design is different for a disease like cancer, where a patient rarely recovers without some type of treatment, and this virus that can be survived without intervention, and that varies in impact from a mild flu to death.
In a previous post, I said I would take my chances if I was dying and "roll the dice". If there is more than one treatment option, I will trust men like you to advise me of the best course of treatment. If there are no options, and I need to be a guinea pig for testing, I am OK with that. The "hope" that the current "fad" gives us is that it may work...and it will not kill us. In the worst case, Covid-19 or the defense reaction (cytokine storm} will kill many of those with severe cases within days. Most of us are ignorant...maybe we are being fooled...but we are not aware of any other options.
Actually it would be much faster to do coronavirus trials than cancer trials. Many more patients and much faster clinical course. I have no specific knowledge but I’m almost certain there are multiple well designed trials underway now. And, you’re gonna hear about them first via NEJM or Lancet or from Fauci, not YouTube.
Cytokine “storm” is probably the most important target. Coronavirus doesn’t seem to grow uncontrollably and destroy lung tissue directly. It’s more likely that it just triggers a host reaction (cytokine storm) that is much more severe in some people than others. Same phenomenon is seen with other infectious diseases. We don’t know enough about host immune genetics yet to predict which patients are at highest risk and we don’t have any really effective therapies yet either.
Cytokine storm is kinda like what might happen if you called the fire department to put out a fire in your basement and their response was to fill the basement with water, drowning anyone there.