I have a fleet of F150s with Ecoboost engines. One had over 400,000 when I sold it to an employee that still is driving it. That one was 2013 3.5. Mine is a 2021 with 128,000 still running good on original plugs. Mine is the Max Tow package and I have been having issues with an axle bolt breaking. It has a recall on it but they have not found a solution yet.
A couple of them are 2020 models with the 2.7 and have over 200,000. I have one 2020 with 2.7 and 168,000 now that does have transmission issues. It is a valve body problem that tries to shift to 1st at highway speeds. The clutches were slipping some but not bad and not all the time. I just ordered a replacement improved transmission for it for $4,000. We will replace it in our shop.
Over all very satisfied with these trucks and will continue buying them as we replace them or have new needs. We do change the oil every 5,000 or so miles with full synthetic oil.