I've been "on the road again" for about a quarter of my life since college in '74. There was a slight decline when I got to my posting at Ft. Belvoir, Va in '75 but by '76 I was usually travelling at least a full week each month, plus a month of annual vacation. From the leveling of the Towers until I retired in 2011 that was upped to often 3 weeks a month on the road.
Then my wife and I retired. And found ourselves "retiring to Mississippi" (where her mother lives) from Ft. Belvoir area at the rate of a few months here, a few months there and a 14 hour "commute".
So we generally have each of our bags pretty much packed ALL the time. Swap out the wool socks, swap in the shorts type thing. Then there are two laptop bags (one contains a Mobley), our individual "meds bag", an "important papers" bag, a food bag/box and we are ready to go.
So the couple of times we've had a nearby "emergency" it's been an easy grab of a couple of bags and we, or one of us, is on the road again.
For example - This last summer my MIL had a fall, SWMBO grabbed clothes bag, purse, her meds bag, laptop bag and was gone in 15 minutes.