The key thing about spraying herbicides like 2-4-d is you need to pick you spot in time. Like others have said, a surfactant will help, but you need to spray when the plant is transpiring--e.g. breathing. If it is too hot or the plant is is draught stressed, the openings on the plant leaves will be closed and the plant will not absorb the herbicide. Also, when you spray in the plant's life cycle during the season is important. The goal is to get as much of the herbicide into the plants root system. You want to spray when the ground temps are up, the plant has leafed out but before it has started to set seed or after the seed has dropped. If you spray as the plant is leafing out or as it is setting seed, the plant is sending nutrients from the roots to the top of the plant and systematic herbicides will not be as effective. However, if you spray as the plant is recharging its roots (i.e. after leaf out and before setting seed or after seed drop) the plant is "recharging" the root system and will be primarily sending nutrients (and any herbicides) from the leaves to the roots--which is what you want.